Degree programme
Programme Structure
Show/Search Programme
Course Details
Save Document
Degree Programme
Read Degree Programme
Quantitative data
International context
Customized Schedule
Your customized time schedule has been disabled
Search a Lecturer
Search a Course
Search a Course (system prior D.M. n. 509)
Search Lessons taught in English

Semester (Sem)
1First Semester
2Second Semester
AAnnual course
Educational activities
CSimilar or integrative activities
Course completely offered in italian
Course completely offered in english
--Not available
Innovative teaching
The credits shown next to this symbol indicate the part of the course CFUs provided with Innovative teaching.
These CFUs include:
  • Subject taught jointly with companies or organizations
  • Blended Learning & Flipped Classroom
  • Massive Open Online Courses (MOOC)
  • Soft Skills
Course Details
Academic Year 2018/2019
School School of Industrial and Information Engineering
Name (Bachelor of Science degree)(ord. 270) - MI (347) Chemical Engineering
Track N1L - Ingegneria Chimica
Programme Year 3

Course Details
ID Code 052380
Course Type Mono-Disciplinary Course
Credits (CFU / ECTS) 5.0
Semester Second Semester
Course Description Course Aims The Biocompatibility and cell culture Laboratory aims at (1) describing the current regulations on biological safety; (2) presenting the techniques and assays for cell culturing; (3) discussing protocols and assays for the in vitro biological validation of biomedical materials and devices. Lessons The lessons will be focused on the following topics: (a) current regulations related to the classification of the biological laboratories and biological agents, risk assessment; safety rules and good laboratory practice; (b) biological environment-material interaction; (c) cell culture techniques, in particular referred to culture media, cell models, techniques, equipment and assays for cell culturing and cell response assessment; (d) in vitro biological validation of materials and biomedical devices: models and assays; (e) overview on in vivo biological validation of materials and biomedical devices; (f) design and execution of experimental protocols. Laboratory activity The laboratory activities will be assigned to groups of 4/5 students and will be focused on: (a) cell culture techniques: defrosting, expansion, cryopreservation; (b) cell seeding and culturing on polymeric/metallic/ceramic materials; (c) samples treatment and in vitro cell response assessment. Other activities To complement the described activities and to stimulate active learning, the structuring skills of thinking and knowledge and the assessment among colleagues, each group of students will be asked to prepare a selected "case study" assigned by the lecturer, related to the course topics, that will be discussed with the other classmates in flipped classroom modality and also with external lecturers/scientists. Expected acquired knowledge At the end of the course, students are expected to: (a) have a good knowledge about the theory and the practical aspects to design and discuss an in vitro validation protocol for biomedical devices; (b) have acquired the basic knowledge of the in vivo biological assays; (c) critically discuss the methods and results of in vitro biocompatibility assays described in literature. Exam The exam has a written and an oral part: (a) the written part of the exam requires the production of a report based on the experimental activities performed in the laboratory activities; (2) the oral part requires the presentation and the discussion with the lecturer of the previously mentioned report content and an in depth discussion to evaluate the topics treated during the lessons. Further information To attend the course, a basic knowledge of cell biology is suggested. The language of the course is Italian. The attendance of the lessons and laboratory actitivies is mandatory, In particular, the participation to the lessons focused on biological risks and chemical risks is mandatory to access to the laboratory activities. The teaching materials will be provided by the lecturer during the course through the related BEEP portal. This is a limited number access course: the mandatory procedure for the admission is available at http://www.ccsbio.polimi.it/?page_id=27
Scientific-Disciplinary Sector (SSD)
Educational activities SSD Code SSD Description CFU
Innovative teaching The course includes  1.0  credits in Innovative Teaching as follows:
  • Blended Learning & Flipped Classroom

Schedule, add and removeAlphabetical groupLecturer(s)LanguageTeaching Assignment Details
From (included)To (excluded)
---AZZZZGiordano Carmen
manifesti v. 3.7.1 / 3.7.1
Area Servizi ICT